![]() ![]() It has been reported that between 7.5% and 100% of AD patients have leukoaraiosis. In addition to the predominantly cortical atrophy shown on CT scan, 1 MRI has demonstrated white matter lesions induced by cerebral hypoperfusion known as leukoaraiosis. The association of cerebral hypoperfusion and Alzheimer disease (AD) is well established. To prevent the formation of watershed cortical microinfarcts in AD, monitoring blood pressure and treating arterial hypotension are essential. Perturbed hemodynamic factors (eg, decreased blood pressure) may play a role in the genesis of cortical watershed microinfarcts.Ĭonclusions- In AD, cerebral hypoperfusion induces not only white matter changes but cortical watershed microinfarcts as well, further aggravating the degenerative process and worsening dementia. Congophilic angiopathy was revealed to be an important risk factor. ![]() The microinfarcts were restricted to the watershed cortical zones. Results- A significant association ( P=0.001) was found between the occurrence of watershed cortical infarcts and AD (32.4% versus 2.5% in controls). The 3-dimensional reconstruction of the whole cerebrum, with 3-mm spaced serial sections, was performed in 6 AD cases to study the intrahemispheric and interhemispheric distribution of the cortical microinfarcts. Methods- Brains of 184 autopsy cases (105 definite AD cases and 79 age-matched controls) were selected and analyzed by histochemical and immunohistochemical techniques. Cerebral hypoperfusion is associated with Alzheimer disease (AD), but information regarding the occurrence of watershed cortical infarcts in AD is lacking.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
December 2022
Categories |